Does TGF-beta protect articular cartilage in vivo?

Agents Actions Suppl. 1993;39:127-31. doi: 10.1007/978-3-0348-7442-7_14.

Abstract

Repeated intraarticular injections of transforming growth factor beta cause stimulation of articular cartilage proteoglycan synthesis, influx of inflammatory cells, fibrosis and osteophyte formation. When injected together with interleukin-1, TGF-beta enhances IL-1 induced cell-attraction in a synergistic way, while it counteracts IL-1 induced suppression of cartilage PG synthesis.

MeSH terms

  • Animals
  • Arthritis, Experimental / metabolism
  • Arthritis, Experimental / pathology
  • Cartilage, Articular / drug effects*
  • Cartilage, Articular / metabolism
  • Cartilage, Articular / pathology
  • Injections
  • Interleukin-1 / pharmacology
  • Mice
  • Mice, Inbred C57BL
  • Proteoglycans / biosynthesis
  • Sulfates / metabolism
  • Transforming Growth Factor beta / administration & dosage
  • Transforming Growth Factor beta / pharmacology*

Substances

  • Interleukin-1
  • Proteoglycans
  • Sulfates
  • Transforming Growth Factor beta