Intestinal perforation from gastrointestinal histoplasmosis in acquired immunodeficiency syndrome. Case report and review of the literature

Arch Surg. 1993 Apr;128(4):464-6. doi: 10.1001/archsurg.1993.01420160106018.


Gastrointestinal involvement with histoplasmosis in patients with the acquired immunodeficiency syndrome is a rare but documented phenomenon. Most patients present with diarrhea, fever, and abdominal pain. We present a case of a woman who tested positive for the human immunodeficiency virus antibody who developed an intestinal perforation due to Histoplasma capsulatum of the ileum. The patient, whose only risk factor was a blood transfusion 8 years earlier, had been previously diagnosed as having disseminated histoplasmosis with gastrointestinal involvement. While receiving oral antifungal treatment (itraconazole), she developed two separate areas of ileal perforation due to H capsulatum. Complications from gastrointestinal involvement with histoplasmosis, such as perforation, should be considered in patients infected with the human immunodeficiency virus with signs and symptoms suggesting abdominal disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Adult
  • Female
  • Gastroenteritis / complications*
  • Histoplasmosis / complications*
  • Humans
  • Ileal Diseases / etiology*
  • Intestinal Perforation / etiology*