HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease

Arthritis Rheum. 1993 Apr;36(4):465-72. doi: 10.1002/art.1780360406.


Objective: To examine the distribution of HLA class II alleles in clinically distinct juvenile rheumatoid arthritis (JRA) subsets.

Methods: We typed 298 patients and 181 controls for HLA-DRB1, DQA1, DQB1, and DPB1 alleles using polymerase chain reaction and oligonucleotide probe techniques.

Results: Each JRA subset was characterized by a distinct distribution of HLA class II alleles. For the persistently pauciarticular and rheumatoid factor-negative polyarticular JRA subsets, certain combinations of DRB1 and DPB1 alleles were characteristic. In patients without antinuclear antibodies and chronic iridocyclitis, there was an increase of DRB1*0101/02 and DQA1*0101.

Conclusion: Findings of HLA typing support clinical subdivisions of the disease and suggest the existence of a novel DRB1*0101/02 and DQA1*0101 associated disease subset.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / genetics
  • Alleles
  • Antibodies, Antinuclear / blood
  • Arthritis, Juvenile / epidemiology
  • Arthritis, Juvenile / genetics*
  • Arthritis, Juvenile / immunology*
  • Child
  • Child, Preschool
  • Female
  • HLA-DP Antigens
  • HLA-DQ Antigens / genetics
  • HLA-DQ alpha-Chains
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Histocompatibility Antigens Class II / genetics*
  • Histocompatibility Testing
  • Humans
  • Infant
  • Iridocyclitis / blood
  • Iridocyclitis / immunology
  • Male
  • Risk Factors


  • Antibodies, Antinuclear
  • HLA-DP Antigens
  • HLA-DQ Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQA1 antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Histocompatibility Antigens Class II