Quantitative 31P MRS of the normal adult human brain. Assessment of interindividual differences and ageing effects

NMR Biomed. Jan-Feb 1993;6(1):53-7. doi: 10.1002/nbm.1940060109.


The characteristics of the 31P MR spectra from a large central volume in the brain of 47 healthy adults (aged 25-85 years) were assessed. Spectral parameters were estimated by means of a time-domain fitting technique. Statistical uncertainties of the estimates were determined by means of the Cramer-Rao theory and minimized by introducing a priori knowledge into the fitting procedure. Age-dependency of the spectral parameters was assessed by means of linear regression. Significant differences between individuals were established for some parameters. A significant age-dependency (p < or = 0.001) of ca 20% over the age range considered was found for the intensity of the phosphocreatine resonance line.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Brain / metabolism*
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Individuality
  • Magnetic Resonance Spectroscopy / methods
  • Male
  • Middle Aged
  • Phosphocreatine / metabolism
  • Phosphorus / metabolism*


  • Phosphocreatine
  • Phosphorus
  • Adenosine Triphosphate