A sclerodermatous syndrome with unusual features following prolonged occupational exposure to organic solvents

Br J Dermatol. 1993 Feb;128(2):203-6. doi: 10.1111/j.1365-2133.1993.tb15152.x.


We describe a sclerodermatous syndrome in a middle-aged man who had worked with a wide variety of organic solvents over a prolonged period. Associated changes included cold sensitivity, a restrictive lung defect, peripheral neuropathy, oesophageal dysfunction, labile hypertension and a monoclonal paraproteinaemia. This unique syndrome is discussed in relation to other disorders associated with exposure to organic solvents.

Publication types

  • Case Reports

MeSH terms

  • Azathioprine / therapeutic use
  • Chemical Industry*
  • Humans
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / drug therapy
  • Prednisolone / therapeutic use
  • Scleroderma, Systemic / chemically induced*
  • Scleroderma, Systemic / drug therapy
  • Solvents / adverse effects*


  • Solvents
  • Prednisolone
  • Azathioprine