Rat intestinal epithelial cell line IEC-6 is activated by recombinant interferon-gamma to inhibit replication of the coccidian Toxoplasma gondii

Eur J Immunol. 1993 Apr;23(4):981-3. doi: 10.1002/eji.1830230435.


Toxoplasma gondii tachyzoites invaded and replicated in cultured rat small intestine cells of the line IEC-6. Treatment of rat small intestine cells with murine recombinant interferon-gamma resulted in a dose-dependent inhibition of intracellular T. gondii replication. This could be of relevance as a first line defense against Toxoplasma infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • In Vitro Techniques
  • Interferon-gamma / pharmacology*
  • Intestinal Mucosa / parasitology*
  • Rats
  • Recombinant Proteins
  • Toxoplasma / growth & development*
  • Toxoplasma / immunology


  • Recombinant Proteins
  • Interferon-gamma