Molecular cloning and characterization of the human E-cadherin cDNA

Mol Biol Rep. 1993 Feb;17(2):123-8. doi: 10.1007/BF00996219.


E-cadherin is a Ca(2+)-dependent cell adhesion molecule involved in cell-cell interaction. In its normal physiological function it plays an important role in embryonic development and tissue morphogenesis. Recent studies have shown that in cancer development E-cadherin can act as a suppressor of invasion. Indeed, in several kinds of carcinomas allelic loss of the E-cadherin/Uvomorulin locus and decreased E-cadherin expression have been described. The importance of E-cadherin in human cancer development may be substantiated by molecular analysis of the E-cadherin transcript. Therefore, we isolated and characterized the human E-cadherin cDNA. Comparison of the nucleotide and deduced amino acid sequences revealed that the human E-cadherin is highly homologous to the mouse E-cadherin (uvomorulin) and to other members of the cadherin family.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cadherins / genetics*
  • Cloning, Molecular
  • DNA / genetics*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid


  • Cadherins
  • DNA

Associated data

  • GENBANK/Z13009