D-lactate metabolism in patients with chronic renal failure undergoing CAPD

Nephron. 1993;63(4):416-22. doi: 10.1159/000187245.

Abstract

To clarify the D-lactate metabolism in patients with chronic renal failure undergoing CAPD, plasma levels, loaded doses and urinary excretion of D-lactate were measured. In addition, D-2-hydroxy acid dehydrogenase activities in resected and autopsied specimens were measured. The daily loaded dose of D-lactate by CAPD was 88.9 +/- 1.29 mmol and urinary excretion was negligible. There was no tendency for the plasma D-lactate to accumulate. The enzyme activity was detected in the liver, kidney and pancreas tissues both in the resected and autopsied specimens. The above findings indicate that the loaded D-lactate is catabolized in patients with chronic renal failure undergoing CAPD, and D-2-hydroxy acid dehydrogenase is responsible for the metabolism of D-lactate in humans.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alcohol Oxidoreductases / metabolism
  • Dialysis Solutions
  • Female
  • Humans
  • Kidney / enzymology
  • Kidney Failure, Chronic / metabolism*
  • Kidney Failure, Chronic / therapy*
  • L-Lactate Dehydrogenase*
  • Lactate Dehydrogenases*
  • Lactates / administration & dosage
  • Lactates / blood
  • Lactates / metabolism*
  • Lactic Acid
  • Liver / enzymology
  • Male
  • Middle Aged
  • Pancreas / enzymology
  • Peritoneal Dialysis, Continuous Ambulatory*

Substances

  • Dialysis Solutions
  • Lactates
  • Lactic Acid
  • Alcohol Oxidoreductases
  • Lactate Dehydrogenases
  • L-Lactate Dehydrogenase
  • D-lactate dehydrogenase
  • D-2-hydroxyacid dehydrogenase