Structure and promoter organization of the human monoamine oxidase A and B genes

J Psychiatry Neurosci. 1993 Jan;18(1):25-32.


Monoamine oxidase (MAO) A and B play an important role in regulating levels of biogenic amines. MAO A and B cDNAs have been cloned and the deduced amino acids share 73% sequence identity. The genes for MAOA and B are comprised of 15 exons interspersed by 14 introns, span at least 60 kb and exhibit identical exon-intron organization. These findings suggest that the MAOA and MAOB genes are derived from the duplication of a common ancestral gene. The core promoter region of MAOA is comprised of two 90 bp repeats, each of which contains two Spl elements and lacks a TATA box. The MAOB core promoter region contains two sets of overlapping Spl sites which flank a CACCC element all upstream of a TATA box. The different organization of the MAOA and MAOB promoters may underlie their different cell and tissue specific expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence / genetics
  • Cloning, Molecular
  • Female
  • Genomic Library
  • Humans
  • Male
  • Molecular Sequence Data
  • Monoamine Oxidase / genetics*
  • Promoter Regions, Genetic / genetics*
  • Transcription, Genetic


  • Monoamine Oxidase