ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls

Addiction. 1993 Mar;88(3):383-8. doi: 10.1111/j.1360-0443.1993.tb00825.x.


Eighty-two Caucasian patients receiving treatment for alcohol-related problems and eighty four controls were DNA typed for variants in the alcohol dehydrogenase (ADH2 and ADH3) and mitochondrial aldehyde dehydrogenase (ALDH2) gene loci. No association was observed between individual, or combined gene frequencies and the presence of alcohol-related problems.

MeSH terms

  • Adult
  • Alcohol Dehydrogenase / genetics*
  • Alcoholism / genetics*
  • Aldehyde Dehydrogenase / genetics*
  • Female
  • Gene Frequency
  • Genotype*
  • Humans
  • Isoenzymes / genetics*
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Risk Factors
  • United Kingdom


  • Isoenzymes
  • Alcohol Dehydrogenase
  • Aldehyde Dehydrogenase