Expression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta

J Clin Pathol. 1993 Mar;46(3):204-7. doi: 10.1136/jcp.46.3.204.

Abstract

Aims: To compare the expression of c-myc and c-fms proto-oncogenes in the placenta and hydatidiform mole.

Methods: Twelve hydatidiform moles and six induced abortion cases were collected. c-myc and c-fms proto-oncogene expression was analysed by northern blot hybridisation and immunohistochemical staining.

Results: The results of northern blot hybridisation analysis showed that c-fms was expressed more strongly in hydatidiform moles compared with normal placenta of similar gestational age. Moreover, c-fms mRNA concentrations increased with more advanced gestational age in moles but not in normal placentas. c-myc expression was very low in hydatidiform moles and normal placentas. Both oncogenes, however, had no direct correlation with the clinical course of the molar pregnancies.

Conclusion: The difference in c-fms expression between hydatidiform moles and normal placentas suggests that c-fms may have a role in the development of molar pregnancies.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • Blotting, Northern
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gestational Age
  • Humans
  • Hydatidiform Mole / chemistry*
  • Hydatidiform Mole / genetics
  • Immunoenzyme Techniques
  • In Situ Hybridization
  • Placenta / chemistry*
  • Pregnancy
  • Proto-Oncogene Proteins c-myc / analysis*
  • Proto-Oncogene Proteins c-myc / genetics
  • RNA, Messenger / analysis
  • Receptor, Macrophage Colony-Stimulating Factor / analysis*
  • Receptor, Macrophage Colony-Stimulating Factor / genetics
  • Trophoblasts / chemistry*
  • Uterine Neoplasms / chemistry*
  • Uterine Neoplasms / genetics

Substances

  • Antibodies, Monoclonal
  • Proto-Oncogene Proteins c-myc
  • RNA, Messenger
  • Receptor, Macrophage Colony-Stimulating Factor