Differentiation of systemic juvenile rheumatoid arthritis from acute leukemia near the onset of disease

J Pediatr. 1993 Apr;122(4):595-8. doi: 10.1016/s0022-3476(05)83543-7.


Many children with acute leukemia have musculoskeletal complaints and non-specific hematologic abnormalities. A total of 10 children with acute leukemia and 10 with systemic juvenile rheumatoid arthritis were compared to delineate which early features could differentiate these diagnoses. Attention to evolving hematologic abnormalities and musculoskeletal findings may expedite diagnosis of these diseases.

Publication types

  • Comparative Study

MeSH terms

  • Arthritis / etiology
  • Arthritis, Juvenile / diagnosis*
  • Arthritis, Juvenile / epidemiology
  • Child
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Muscular Diseases / etiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
  • Retrospective Studies