Report on a case of amyloidosis in the orbits of a 81-year-old women with 20 year's follow up. At first examination she presented with cystic changes of the palpebral conjunctiva and spontaneous hematoma of the lid. Preceding diagnosis by biopsy six years of unspecific local therapy with various eye drops followed then by cryotherapy and two surgical interventions. Discussion of primary localized amyloidosis and other variants of amyloidosis and therapeutic approach.