Diffusion imaging of experimental allergic encephalomyelitis

Magn Reson Med. 1993 Apr;29(4):478-84. doi: 10.1002/mrm.1910290409.


Diffusion-weighted magnetic resonance imaging (MRI) was compared with T2-weighted MRI in longitudinal studies of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, in five monkeys (Macaca fascicularis). In a region of the brain that had highly directional myelinated fibers (internal capsule) sequential changes were identified on diffusion-weighted images on and before the day these changes were detected on conventional T2-weighted images. Changes were also identified on diffusion-weighted images in brain areas that did not develop T2-weighted abnormalities. This result suggests that diffusion-weighted image intensities are sensitive to pathologic conditions of the brain that can not be seen on T2-weighted images.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Brain / pathology*
  • Encephalomyelitis, Autoimmune, Experimental / diagnosis*
  • Macaca fascicularis
  • Magnetic Resonance Imaging / methods*
  • Male
  • Multiple Sclerosis / diagnosis