Albendazole as a treatment for infections with Giardia duodenalis in children in Bangladesh

Trans R Soc Trop Med Hyg. Jan-Feb 1993;87(1):84-6. doi: 10.1016/0035-9203(93)90435-s.

Abstract

Albendazole, a broad spectrum anthelmintic recently shown to be active in vitro against Giardia duodenalis, was given at 4 different dosages and compared with metronidazole in the treatment of children in Bangladesh infected with Giardia. Three stools were collected over 10 d after treatment and examined microscopically. Albendazole was found to be effective: single doses of either 600 mg (n = 103) or 800 mg (n = 114) successfully treated 62% and 75% of infections, respectively; 400 mg given either once a day for 3 d (n = 116) or for 5 d (n = 115) successfully treated 81% and 95% of all infections, respectively. Albendazole given daily at 400 mg for 5 d was as effective as metronidazole, which cured 97% of infections (n = 230). Albendazole may thus be an alternative treatment for infections with Giardia, while the moderate efficacy of single doses may provide a benefit in addition to its effects on several species of intestinal helminths.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albendazole / administration & dosage
  • Albendazole / therapeutic use*
  • Animals
  • Bangladesh
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Duodenal Diseases / parasitology
  • Feces / parasitology
  • Giardia lamblia / isolation & purification
  • Giardiasis / drug therapy*
  • Giardiasis / parasitology
  • Humans
  • Metronidazole / therapeutic use
  • Treatment Outcome

Substances

  • Metronidazole
  • Albendazole