Genetic models for the natural history of smoking: evidence for a genetic influence on smoking persistence

Addict Behav. 1993 Jan-Feb;18(1):19-34. doi: 10.1016/0306-4603(93)90005-t.


We reanalyze data from the 1981 mailed questionnaire survey of the Australian twin register, to test for a genetic effect on smoking persistence (whether or not a smoker quits smoking). In the young cohort, aged 18-30 years, there are too few ex-smokers to permit resolution of genetic and non-genetic models. In the older cohort, we find a significant and substantial genetic effect on smoking persistence, accounting for 53% of the variance. This genetic effect on smoking persistence is independent of genetic effects on smoking initiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Behavior, Addictive
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Models, Genetic
  • Smoking / genetics*