Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

Cytogenet Cell Genet. 1993;63(2):114-6. doi: 10.1159/000133513.


UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 2*
  • Glucuronosyltransferase / genetics*
  • Humans
  • In Situ Hybridization


  • Glucuronosyltransferase