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. 1993 Feb 19;150(2):145-8.
doi: 10.1016/0304-3940(93)90522-m.

Dimethylsulfoxide (DMSO) Blocks Conduction in Peripheral Nerve C Fibers: A Possible Mechanism of Analgesia

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Dimethylsulfoxide (DMSO) Blocks Conduction in Peripheral Nerve C Fibers: A Possible Mechanism of Analgesia

M S Evans et al. Neurosci Lett. .

Abstract

Dimethylsulfoxide (DMSO) is readily absorbed through skin, and relieves musculoskeletal pain when applied topically to painful areas. We studied the effects of DMSO on C-type nerve fibers, which mediate pain sensation. DMSO was applied directly to exposed cat sural nerves. C fiber conduction velocity was slowed by DMSO, even in low concentrations (5-7% v/v). Higher concentrations completely blocked C fiber conduction, with a minimum blocking concentration of 9%. Onset of nerve block was almost immediate with 15% DMSO or higher concentrations. C fiber blockade may account for analgesia with DMSO.

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