Comparison of topical ciprofloxacin to conventional antibiotic therapy in the treatment of ulcerative keratitis

Am J Ophthalmol. 1993 Apr 15;115(4):471-7. doi: 10.1016/s0002-9394(14)74449-6.


We evaluated the efficacy of ciprofloxacin (3 mg/ml) as the sole topical antibiotic used to treat infectious keratitis in 14 patients. We compared the ciprofloxacin-treated group to a retrospective control group of 30 consecutive culture-positive patients treated with conventional therapy in which cefazolin (50 mg/ml) and fortified gentamicin sulfate (9.1 mg/ml) solutions were used. We found no remarkable difference between the control group and the ciprofloxacin-treated group regarding patient age, risk factors, need for hospitalization, and virulence of organism isolated. The average time to healing in culture-positive ciprofloxacin-treated patients was 34 +/- 33 days vs 45 +/- 71 days in the control group and this difference was not statistically significant. The duration of antibiotic therapy in the culture-positive ciprofloxacin-treated group was 27 +/- 15 days vs 33 +/- 50 days in the control group. Four of the 30 control patients required modification of their antibiotic regimen, whereas no ciprofloxacin-treated patient required a change. Ciprofloxacin appears to be an effective single agent in the treatment of ulcerative keratitis.

Publication types

  • Case Reports
  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Infections / drug therapy*
  • Cefazolin / administration & dosage
  • Ciprofloxacin / therapeutic use*
  • Corneal Ulcer / drug therapy*
  • Corneal Ulcer / microbiology
  • Drug Therapy, Combination / therapeutic use
  • Eye Infections, Bacterial / drug therapy*
  • Female
  • Gentamicins / administration & dosage
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Retrospective Studies


  • Gentamicins
  • Ciprofloxacin
  • Cefazolin