The reproducibility of quinine bioavailability

Br J Clin Pharmacol. 1993 Mar;35(3):305-7. doi: 10.1111/j.1365-2125.1993.tb05698.x.

Abstract

Plasma concentrations of quinine were measured in six healthy volunteers after a duplicate administration of 15 mg kg-1 of quinine hydrochloride orally and the administration of 15 mg kg-1 of quinine dihydrochloride as an infusion over 6 h. Quinine absorption rate devised by deconvolution was shown to be complete in less than 2 h. The mean (+/- s.d.) fraction available (F) was 0.76 (0.11) after both oral doses and maximum plasma drug concentrations occurred at 1.90 (0.83) h and 2.00 (0.30) h, respectively. The reproducibility of absorption was high, with a within-subject coefficient of variation of less than 10% for Cmax, AUC and F. Thus, quinine absorption is extensive, fast and reproducible in healthy volunteers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Biological Availability
  • Chromatography, High Pressure Liquid
  • Female
  • Humans
  • Infusions, Intravenous
  • Intestinal Absorption
  • Male
  • Quinine / administration & dosage
  • Quinine / blood
  • Quinine / pharmacokinetics*

Substances

  • Quinine