Properties of single Na(+)-activated K+ channels in cultured central neurons of the chick embryo

Neurosci Lett. 1993 Jan 12;149(2):133-6. doi: 10.1016/0304-3940(93)90754-9.


Na(+)-activated K+ channels (IK[Na]) of cultured chick brainstem neurons do not run down following excision of inside-out patches, but this occurs within seconds to minutes in cultured chick olfactory bulb neurons. IK[Na] channels of chick brainstem neurons exhibit a main conductance state of 95-105 pS, and also express multiple sub-conductance states. These channels have complex kinetics, with multiple closed and main conductance states. The average lifetime of the main conductance state is not dependent on the Na+ concentration used to activate the channels.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Stem / metabolism
  • Brain Stem / physiology
  • Cells, Cultured
  • Chick Embryo
  • Ion Channel Gating / physiology
  • Kinetics
  • Neurons / metabolism*
  • Neurons / physiology
  • Olfactory Bulb / embryology
  • Olfactory Bulb / metabolism*
  • Potassium Channels / metabolism*
  • Potassium Channels / physiology
  • Sodium / physiology*


  • Potassium Channels
  • Sodium