The role of the practice nurse in the management of depression in general practice: treatment adherence to antidepressant medication

Psychol Med. 1993 Feb;23(1):229-37. doi: 10.1017/s0033291700039027.


This pilot study demonstrated the feasibility of providing practice nurse support as an adjunct to standard general practitioner treatment to patients with depressive disorders prescribed antidepressant medication. With respect to the measures used and pilot study objectives identified, there were no statistically significant differences between the study groups in treatment adherence to the prescription of antidepressant medication or in the incidence and severity of adverse events to medication. Large-scale randomized controlled trials are in progress to assess the effectiveness of practice nurse interventions in the management of depressive illness in general practice.

MeSH terms

  • Adult
  • Aged
  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / therapeutic use
  • Depressive Disorder / drug therapy*
  • Dothiepin / administration & dosage
  • Dothiepin / therapeutic use*
  • Family Practice
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nurse Practitioners* / education
  • Nurse-Patient Relations
  • Pilot Projects
  • Workforce


  • Antidepressive Agents
  • Dothiepin