Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice

Transplantation. 1993 Apr;55(4):718-22. doi: 10.1097/00007890-199304000-00006.


Despite extensive study, the immunologic mechanisms mediating allograft rejection have not been completely defined. In the current study, we evaluated the T cell subsets important in islet allograft, skin allograft, and islet xenograft rejection using a genetically engineered line of mice deficient in beta 2-microglobulin expression. Because these mice lack cell surface MHC class I expression, they are deficient in T cells of the CD8 subset (class I-restricted cytotoxic T cells). Pancreatic islet allografts transplanted to CD8+ T cell-deficient recipients showed prolonged survival compared with controls. No prolongation was observed in the survival of pancreatic islet xenografts or in the survival of skin allografts transplanted to the CD8+ T cell--deficient hosts. We conclude that CD8+ T cells play a prominent role in islet allograft, but not islet xenograft or skin allograft, rejection in mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CD8 Antigens / analysis*
  • Graft Rejection / immunology
  • Graft Survival / physiology
  • Islets of Langerhans Transplantation / immunology*
  • Male
  • Mice
  • Skin Transplantation / immunology*
  • T-Lymphocytes / immunology*
  • Transplantation, Heterologous / immunology*
  • Transplantation, Homologous / immunology*


  • CD8 Antigens