Memory expression is blocked by the infusion of CNQX into the hippocampus and/or the amygdala up to 20 days after training

M Bianchin; R Walz; A C Ruschel; M S Zanatta; R C Da Silva; M Bueno e Silva; N Paczko; J H Medina; I Izquierdo

doi:10.1016/0163-1047(93)90782-d

Memory expression is blocked by the infusion of CNQX into the hippocampus and/or the amygdala up to 20 days after training

Behav Neural Biol. 1993 Mar;59(2):83-6. doi: 10.1016/0163-1047(93)90782-d.

Authors

M Bianchin¹, R Walz, A C Ruschel, M S Zanatta, R C Da Silva, M Bueno e Silva, N Paczko, J H Medina, I Izquierdo

Affiliation

¹ Departamento de Bioquimica, Instituto de Biociencias, U.F.R.G.S., Porto Alegre, RS, Brazil.

PMID: 8476386
DOI: 10.1016/0163-1047(93)90782-d

Abstract

Bilateral infusion of CNQX (0.5 microgram) into the amygdala and the dorsal hippocampus prior to a retention test blocked the expression of step-down inhibitory avoidance in rats 6, 13, or 20 days after training. Retention test performance recovered 90 min after the infusions. Pretest intrahippocampal CNQX (0.5 microgram) blocked the expression of habituation to a novel environment measured 20 days after training. The data suggest that memory expression depends on non-NMDA receptor-mediated mechanisms, perhaps the expression of LTP, up to at least 20 days after acquisition. These mechanisms operate in the hippocampus in both tasks and in the amygdala in the avoidance task.

MeSH terms

Amygdala / drug effects*
Animals
Avoidance Learning
Habituation, Psychophysiologic
Hippocampus / drug effects*
Male
Memory Disorders / chemically induced*
Quinoxalines / adverse effects*
Rats
Retention, Psychology

Substances

Quinoxalines