HuMig: a new human member of the chemokine family of cytokines

Biochem Biophys Res Commun. 1993 Apr 15;192(1):223-30. doi: 10.1006/bbrc.1993.1403.


Characterization of lymphokine-activated genes in mouse macrophages led to the identification previously of Mumig, an interferon-gamma-inducible murine gene that encodes a member of the chemokine family of cytokines. The Mumig cDNA probe was used to screen a cDNA library prepared from cultures of the THP-1 human monocytic cell line that had been treated with interferon-gamma. This led to the identification of Humig, a new human member of the chemokine gene family. Humig is induced in THP-1 cells and in peripheral blood mononuclear cells by interferon-gamma but not by interferon-alpha or by lipopolysaccharide. Analysis of mouse and human genomic DNAs suggested that the Mumig and Humig genes are true mouse-human homologues. The Humig mRNA encodes a predicted secreted HuMig protein of 103 residues, M(r) 11,725.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Chemokine CXCL9
  • Chemokines, CXC*
  • Cytokines / biosynthesis
  • Cytokines / genetics*
  • DNA
  • Humans
  • Intercellular Signaling Peptides and Proteins*
  • Interferon-gamma / pharmacology
  • Mice
  • Molecular Sequence Data
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid


  • CXCL9 protein, human
  • Chemokine CXCL9
  • Chemokines, CXC
  • Cxcl9 protein, mouse
  • Cytokines
  • Intercellular Signaling Peptides and Proteins
  • RNA, Messenger
  • Interferon-gamma
  • DNA

Associated data

  • GENBANK/D12925
  • GENBANK/D25302
  • GENBANK/S64630
  • GENBANK/S64631
  • GENBANK/S64632
  • GENBANK/S64635
  • GENBANK/S64636
  • GENBANK/S64637
  • GENBANK/X72755
  • GENBANK/Z19151