Functional differences of T cells in B-chronic lymphocytic leukemia

Leuk Lymphoma. 1993 Jan;9(1-2):133-40. doi: 10.3109/10428199309148516.


B cell chronic lymphocytic leukemia (B-CLL) is a disease characterized by an accumulation of monoclonal lymphocytes of B cell origin. Although the neoplastic process involves the B lymphocyte compartment, phenotypic and functional defects within the T lymphocyte population implicate their possible role in the pathogenesis of the disease. We analyzed the functional and morphological integrity of T lymphocytes from the peripheral blood of 64 patients with B-CLL. The activation of B-CLL T cells after PHA stimulation was determined by measuring [3H]-thymidine incorporation, assessing cell numbers in parallel cultures, and by monitoring the lymphocyte subsets during 9 days of cultivation. Our results indicate the presence of three functionally different populations of T cells in the peripheral blood of B-CLL patients. We present evidence for an increased proliferative potential of T lymphocytes from a group of patients with B-CLL.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Antigens, CD / analysis
  • Antigens, Neoplasm / analysis
  • Cell Differentiation
  • Cells, Cultured
  • DNA, Neoplasm / analysis
  • Female
  • Humans
  • Immunologic Deficiency Syndromes / etiology
  • Immunologic Deficiency Syndromes / pathology
  • Kinetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Lymphocyte Activation / drug effects
  • Male
  • Middle Aged
  • Phytohemagglutinins
  • T-Lymphocyte Subsets / drug effects
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / pathology*


  • Antigens, CD
  • Antigens, Neoplasm
  • DNA, Neoplasm
  • Phytohemagglutinins