The Drosophila Tumorous-lethal Hematopoietic Oncogene Is a Dominant Mutation in the Hopscotch Locus

Mol Gen Genet. 1993 Apr;238(1-2):33-7. doi: 10.1007/BF00279527.

Abstract

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Crosses, Genetic
  • Drosophila melanogaster / genetics*
  • Female
  • Genes, Dominant*
  • Genes, Lethal*
  • Genetic Complementation Test
  • Male
  • Mutation*
  • Oncogenes*
  • Recombination, Genetic
  • Temperature
  • Time Factors