RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles

Trends Biochem Sci. 1993 Mar;18(3):96-101. doi: 10.1016/0968-0004(93)90161-f.


In the eukaryotic cell cycle, nuclear DNA replication (S phase) and mitosis (M phase) are linked such that replication must be complete before mitosis can begin. In order for this coupling to work, there must be some system for detecting unreplicated DNA and transducing an inhibitory signal to prevent the activation of mitotic factors. The DNA-bound protein RCC1 is involved in this regulatory process since mitosis initiates before DNA synthesis is finished in the absence of RCC1. This has led to the proposal that RCC1 is a signalling molecule, detecting unreplicated DNA and producing the inhibitory signal. However, mutants in RCC1 show defects beyond their inability to regulate the cell cycle, suggesting other roles for the RCC1 protein in the nucleus and thus hitherto unexplored relationships between cell cycle control and other cellular processes.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Cycle
  • Cell Cycle Proteins*
  • Chromosomes / metabolism*
  • DNA Replication
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Drosophila
  • Gene Expression
  • Guanine Nucleotide Exchange Factors*
  • Humans
  • Mitosis
  • Molecular Sequence Data
  • Nuclear Proteins*


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Guanine Nucleotide Exchange Factors
  • Nuclear Proteins
  • RCC1 protein, human