Bacterial-induced activation of erythrocyte T-antigen complicating necrotising enterocolitis: a case report

Eur J Pediatr. 1993 Apr;152(4):325-6. doi: 10.1007/BF01956745.


Erythrocyte Thomsen-Friedenreich crypt antigen (T-antigen) activation is not an uncommon event in infants with severe necrotising enterocolitis (NEC). Transfusion of these infants with blood products containing plasma carries the risk of causing intravascular haemolysis. T-antigen activation is easily detected using a rapid simple lectin agglutination test. Early recognition of T-antigen activation ensures the correct choice of plasma free transfusion therapy. We describe an infant with severe NEC complicated by T-antigen activation and haemolysis.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Tumor-Associated, Carbohydrate / immunology*
  • Clostridium perfringens*
  • Enterocolitis, Pseudomembranous / immunology*
  • Hemolysis
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / immunology*
  • Lymphocyte Activation*
  • Male


  • Antigens, Tumor-Associated, Carbohydrate
  • Thomsen-Friedenreich antigen