Structural modifications associated with the change in Ca2+ sensitivity on activation of m-calpain

FEBS Lett. 1993 May 3;322(1):65-8. doi: 10.1016/0014-5793(93)81112-d.


Autolysis of the Ca(2+)-dependent cysteine protease m-calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca2+ sensitivity. The appearance of increased Ca2+ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium / metabolism*
  • Calpain / chemistry
  • Calpain / metabolism*
  • Enzyme Activation
  • Humans
  • Kidney / enzymology
  • Molecular Sequence Data
  • Protein Conformation
  • Swine


  • Calpain
  • Calcium