Basal and histamine-induced gastric acid secretion in alloxan diabetic rats

Gen Pharmacol. 1993 Jan;24(1):121-6. doi: 10.1016/0306-3623(93)90021-o.


1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / physiopathology*
  • Gastric Acid / metabolism*
  • Histamine / pharmacology*
  • Male
  • Rats
  • Rats, Wistar


  • Histamine