Appenolides A-C: three new antifungal furanones from the coprophilous fungus Podospora appendiculata

J Nat Prod. 1993 Mar;56(3):341-4. doi: 10.1021/np50093a005.

Abstract

Appenolides A [1], B [2], and C [3], three new antifungal 2(5H)-furanones, have been isolated from liquid cultures of the coprophilous fungus Podospora appendiculata (UAMH 7225) by repeated preparative tlc on Si gel. The structures were assigned on the basis of nmr and ms data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 4-Butyrolactone / analogs & derivatives
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / isolation & purification
  • 4-Butyrolactone / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Ascomycota / chemistry*
  • Ascomycota / drug effects
  • Bacillus subtilis / drug effects
  • Candida albicans / drug effects
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests

Substances

  • Antifungal Agents
  • appenolide A
  • appenolide B
  • appenolide C
  • 4-Butyrolactone