Abstract
A hot-H2O extract of rhizomes of Anemarrhena asphodeloides, the Japanese sino-medicine "chimo," lowered the blood glucose level in alloxan-diabetic mice. Hypoglycemic activity-guided fractionation isolated a new glycoside, pseudoprototimosaponin AIII [1], which was compared with chemically known prototimosaponin AIII [2]. These compounds exhibited hypoglycemic effects in a dose-dependent manner in streptozotocin-diabetic mice but showed no effects on glucose uptake and insulin release, suggesting that the hypoglycemic mechanism may be due to inhibition of hepatic gluconeogenesis and/or glycogenolysis.
MeSH terms
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Animals
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Blood Glucose / drug effects
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Diabetes Mellitus, Experimental / drug therapy*
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Dose-Response Relationship, Drug
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Glyburide / pharmacology
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Hypoglycemic Agents / isolation & purification*
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use
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In Vitro Techniques
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Insulin / metabolism
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Insulin Secretion
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Islets of Langerhans / drug effects
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Mice, Inbred Strains
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Plants, Medicinal / chemistry*
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Rats
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Rats, Wistar
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Saponins / isolation & purification*
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Saponins / pharmacology
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Saponins / therapeutic use
Substances
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Blood Glucose
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Hypoglycemic Agents
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Insulin
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Saponins
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pseudoprototimosaponin AIII
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Glyburide