C. Elegans lin-45 Raf Gene Participates in let-60 Ras-Stimulated Vulval Differentiation

Nature. 1993 May 13;363(6425):133-40. doi: 10.1038/363133a0.

Abstract

Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / enzymology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins*
  • Cell Differentiation / genetics
  • Cloning, Molecular
  • DNA
  • Female
  • Helminth Proteins / metabolism*
  • Humans
  • Male
  • Molecular Sequence Data
  • Mutation
  • Protein-Serine-Threonine Kinases / genetics*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-raf
  • Sequence Homology, Amino Acid
  • Vulva / cytology*
  • ras Proteins*

Substances

  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Proto-Oncogene Proteins
  • let-60 protein, C elegans
  • DNA
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-raf
  • ras Proteins

Associated data

  • GENBANK/L15347