Change of paraprotein from IgG lambda to lambda chain in myeloma

Ann Hematol. 1993 Apr;66(4):215-6. doi: 10.1007/BF01703239.

Abstract

We describe a unique case of IgG lambda myeloma in which a plasma cell leukemia developed and the paraprotein changed from IgG lambda to lambda chain, the latter inducing fatal renal failure. In addition, J-chain was detected in the cytoplasm of the plasma cell leukemia cells.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / metabolism*
  • Immunoglobulin J-Chains / metabolism*
  • Immunoglobulin lambda-Chains / blood
  • Immunoglobulin lambda-Chains / metabolism*
  • Leukemia, Plasma Cell / blood
  • Leukemia, Plasma Cell / metabolism*
  • Middle Aged
  • Multiple Myeloma / blood
  • Multiple Myeloma / metabolism*

Substances

  • Immunoglobulin G
  • Immunoglobulin J-Chains
  • Immunoglobulin lambda-Chains