Genes for the dimerization cofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and murine chromosomes 10

Genomics. 1993 Apr;16(1):292-5. doi: 10.1006/geno.1993.1182.


Hepatocyte nuclear factor-1 alpha (HNF-1 alpha; gene symbol, TCF1) forms dimers with itself as well as with HNF-1 beta and regulates the expression of several liver-specific genes. Recently, a dimerization cofactor of hepatocyte nuclear factor-1 alpha, called DCOH, has been identified. Here, we report the chromosomal localization of the genes for this cofactor to chromosomes 10 in both humans and mice by Southern blot analyses of somatic cell hybrids.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Southern
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 10*
  • Cricetinae
  • DNA-Binding Proteins / genetics*
  • Humans
  • Hybrid Cells
  • Hydro-Lyases / genetics*
  • Mice
  • Nucleic Acid Hybridization
  • Species Specificity
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Transcription Factors
  • Hydro-Lyases
  • pterin-4a-carbinolamine dehydratase