Long-term results and biocompatibility of heparin-surface-modified intraocular lenses

J Cataract Refract Surg. 1993 Mar;19(2):258-62. doi: 10.1016/s0886-3350(13)80953-4.


A prospective in vivo study of 50 intraocular lenses was done to document the long-term results and biocompatibility of heparin-surface-modified poly(methyl methacrylate) posterior chamber lenses. Continuous curvilinear capsulorhexis and phacoemulsification were performed throughout and examinations were by slit-lamp and specular microscopy. Decentrations of more than 1 mm were seen in 4% of eyes. Stress folds from the haptic traction forces were detected in 16%. A posterior capsulotomy was performed in 10% because of fibrosis or Elschnig pearl formation. Fine fibers were found on the lens surface in 76%. During the first postoperative days only a moderate number of fibroblast-like cells was observed. Foreign-body giant cells were seen in 8%. All cases with foreign-body giant cells had posterior synechias. Visual performance and clinical results were comparable to those of other well-approved intraocular lenses. The low percentage of cellular reaction on the lens surface suggests good biocompatibility.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biocompatible Materials
  • Cataract Extraction
  • Female
  • Fibroblasts / pathology
  • Foreign-Body Reaction / pathology
  • Giant Cells / pathology
  • Heparin*
  • Humans
  • Lenses, Intraocular*
  • Longitudinal Studies
  • Male
  • Methylmethacrylate
  • Methylmethacrylates
  • Middle Aged
  • Prospective Studies
  • Prosthesis Design
  • Treatment Outcome
  • Visual Acuity


  • Biocompatible Materials
  • Methylmethacrylates
  • Methylmethacrylate
  • Heparin