Low-dose-rate irradiation of rat embryo cells containing the Ha-ras oncogene

Radiat Res. 1993 May;134(2):251-5.

Abstract

Rat embryo cells and derived transfectants containing the Ha-ras oncogenes were irradiated with 60Co gamma rays at dose rates of 0.72, 0.066, 0.035, and 0.018 Gy/min. The measured dose response of cell survival shows that the oncogene-containing cells exhibit higher survival levels at all doses than the parental cells at every dose rate. The response of the cells containing the ras oncogene also became dose-rate independent at a higher dose rate, perhaps indicative of a greater repair capability relative to that of the primary cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Survival / radiation effects*
  • Cobalt Radioisotopes
  • Dose-Response Relationship, Radiation
  • Embryo, Mammalian / cytology
  • Embryo, Mammalian / radiation effects*
  • Female
  • Gamma Rays
  • Genes, ras*
  • Pregnancy
  • Rats
  • Rats, Inbred F344
  • Transfection*

Substances

  • Cobalt Radioisotopes