Nerve growth factor revisited

Trends Biochem Sci. 1993 Feb;18(2):48-52. doi: 10.1016/0968-0004(93)90052-o.

Abstract

Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase, as a receptor and (3) it shares homology with at least three other factors, now collectively called neurotrophins, which have a spectrum of target cells.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Nerve Growth Factors / chemistry*
  • Nerve Growth Factors / genetics
  • Protein Conformation
  • Receptors, Nerve Growth Factor / chemistry
  • Structure-Activity Relationship

Substances

  • Nerve Growth Factors
  • Receptors, Nerve Growth Factor