Nerve growth factor revisited

Trends Biochem Sci. 1993 Feb;18(2):48-52. doi: 10.1016/0968-0004(93)90052-o.


Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase, as a receptor and (3) it shares homology with at least three other factors, now collectively called neurotrophins, which have a spectrum of target cells.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Nerve Growth Factors / chemistry*
  • Nerve Growth Factors / genetics
  • Protein Conformation
  • Receptors, Nerve Growth Factor / chemistry
  • Structure-Activity Relationship


  • Nerve Growth Factors
  • Receptors, Nerve Growth Factor