Unrecognized pertussis infection in adolescents

Am J Dis Child. 1993 May;147(5):575-7. doi: 10.1001/archpedi.1993.02160290081031.

Abstract

Little information is available regarding the level of immunity to Bordetella pertussis among adolescents. We measured serum antibodies in 156 healthy adolescents to the following pertussis antigens: pertussis toxin, filamentous hemagglutinin, and 69-kd outer membrane protein. In an attempt to identify intercurrent pertussis infections, we also obtained a total of 43 repeated samples during the following 5 years. Using a 50% or greater rise in IgG enzyme-linked immunosorbent assay titers to define seroconversion, we found an annual incidence of 6.1%; by alternative definitions of seropositivity, the predicted annual incidence of infection ranged from 1.2% to 8.2%. These data suggest that infection with B pertussis is common in the adolescent population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / blood*
  • Bordetella pertussis / immunology*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Pertussis Vaccine
  • Whooping Cough / blood*
  • Whooping Cough / epidemiology
  • Whooping Cough / immunology
  • Whooping Cough / prevention & control

Substances

  • Antibodies, Bacterial
  • Pertussis Vaccine