Successful treatment of cystinuria with captopril

Am J Kidney Dis. 1993 May;21(5):504-7. doi: 10.1016/s0272-6386(12)80396-9.


Cystinuria is an autosomal recessive hereditary disorder associated with nephrolithiasis and its attendant complications. Traditional management aimed at increasing urinary cystine solubility using oral alkali, D-penicillamine, or mercaptopropionyglycine is often unsuccessful due to intolerable side effects. Two cystinuric patients intolerant of traditional therapy were treated with captopril for 1 year, resulting in a marked decline in urinary cystine excretion. Neither patient experienced recurrent nephrolithiasis or adverse drug effects. Captopril should be considered an alternative to traditional drug management of cystinuria.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Captopril / therapeutic use*
  • Cystinuria / drug therapy*
  • Humans
  • Male


  • Captopril