Eosinophil granule major basic protein deposition in corneal ulcers associated with vernal keratoconjunctivitis

Am J Ophthalmol. 1993 May 15;115(5):640-3. doi: 10.1016/s0002-9394(14)71463-1.


An indirect immunofluorescence assay detected eosinophil granule major basic protein in the inflammatory debris covering deepithelialized cornea in two patients with vernal keratoconjunctivitis. A slight degree of non-specific fluorescence was present in the control autopsy corneas. High concentrations of the eosinophil granule major basic protein inhibit epithelial migration and protein synthesis, whereas low concentrations affect epithelial migration. The results suggest participation of eosinophil granule major basic protein in the ulcerative process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Proteins / metabolism*
  • Conjunctivitis, Allergic / complications
  • Conjunctivitis, Allergic / metabolism*
  • Cornea / metabolism
  • Corneal Ulcer / etiology
  • Corneal Ulcer / metabolism*
  • Eosinophil Granule Proteins
  • Eosinophils / metabolism
  • Fluorescent Antibody Technique
  • Humans
  • Microscopy, Fluorescence
  • Ribonucleases*


  • Blood Proteins
  • Eosinophil Granule Proteins
  • Ribonucleases