CDT by anion-exchange chromatography followed by RIA as a marker of heavy drinking among men

Alcohol Clin Exp Res. 1993 Apr;17(2):230-3. doi: 10.1111/j.1530-0277.1993.tb00754.x.

Abstract

Carbohydrate-deficient transferrin, CDT, had previously been reported to be an excellent marker for alcoholism. The present population-based study examined the diagnostic value of CDT among consecutive middle-aged males including 122 social drinkers (mean alcohol consumption 88 +/- 79 g per week) and 77 non-alcoholic heavy drinkers (301 +/- 195 g/wk). Ninety-six men with a well-documented history of chronic alcoholism (> or = 1000 g/wk) were used as a reference group. The CDT (containing mainly isotransferrin with pI = 5.8 and 5.9) was separated by anion exchange chromatography and assayed by RIA. The CDT values of social drinkers (mean +/- SD = 14 +/- 5 U/I) were significantly lower than those of heavy drinkers (19 +/- 13 U/I, p < 0.01) and alcoholics (34 +/- 18 U/I, p < 0.001). In the whole material CDT correlated positively with alcohol consumption (r = 0.53, p < 0.001). At a specificity of 91.8%, CDT found 28.6% of the heavy drinkers and 79.2% of the alcoholics; the best traditional marker, GGT, with a specificity of 86.9%, found 35.1% and 64.6%, respectively. In conclusion, CDT is a specific marker, which is superior to traditional markers for identifying alcoholics. Unfortunately, it does not seem to provide additional power for identifying the important group, non-alcoholic heavy drinkers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcoholism / blood
  • Alcoholism / diagnosis*
  • Alcoholism / rehabilitation
  • Chromatography, Ion Exchange*
  • Humans
  • Liver Function Tests
  • Male
  • Middle Aged
  • Radioimmunoassay*
  • Reference Values
  • Transferrin / analogs & derivatives*
  • Transferrin / analysis

Substances

  • Transferrin
  • carbohydrate-deficient transferrin