Kinevac-assisted cholescintigraphy as an accurate predictor of chronic acalculus gallbladder disease and the likelihood of symptom relief with cholecystectomy

Am Surg. 1993 May;59(5):273-7.


Thirty patients with chronic upper abdominal pain and no evidence of cholelithiasis were entered into this study. All had negative ultrasonography of the gallbladder, and most had a host of other negative investigations. These patients were referred to a surgeon to evaluate the possibility of atypical biliary colic associated with chronic acalculous cholecystitis. All patients underwent cholecystokinin-stimulated cholescintigraphy and were offered cholecystectomy if the ejection fraction was less than 35 per cent. Of the 30 patients, 27 (90%) had pathologically abnormal gallbladders. Follow-up averaged over 1 year (13.2 mo), and relief of symptoms occurred in 28 (94%). The authors conclude that in appropriately selected patients with symptoms of biliary colic (typical or atypical) and no evidence of cholelithiasis, a cholecystokinin-stimulated cholescintigram is a significant help in predicting not only which patients have gallbladder disease, but also how likely cholecystectomy is to result in an improvement in their symptoms.

MeSH terms

  • Adolescent
  • Adult
  • Cholecystectomy
  • Cholecystitis / diagnostic imaging*
  • Cholecystitis / surgery
  • Cholecystography
  • Cholelithiasis / diagnosis
  • Chronic Disease
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain
  • Radionuclide Imaging
  • Sincalide*


  • Sincalide