[Adjuvant treatment of patients with neoplastic lesions using the combination of a vitamin complex and an amino acid. Apropos of a series of 17 cases of epidermoid carcinoma of the upper aerodigestive tract]

Ann Gastroenterol Hepatol (Paris). Mar-Apr 1993;29(2):99-102.
[Article in French]

Abstract

The aim of the work reported here was to evaluate the effects of an adjuvant treatment composed of an association of vitamins with an amino acid: beta-alanine, in cancer patients. This adjuvant therapy has been given to 17 subjects with a squamous cell carcinoma of upper aerodigestive tract treated by radiotherapy most cases were T3 (according to the TNM-UICC). After a 63 months follow-up, 7 patients are alive and sterilized, 4 are alive but no sterilized, 2 died, 4 were excluded from the study. Besides a physical comfort improved in all our patients, we note a restoration of the immune defenses, both humoral and cellular, disturbed by radiotherapy. At last, we note an increase of survival in the patients treated by the adjuvant therapy, compared to a reference population of patients with squamous cell carcinoma of upper aerodigestive tract. Despite the limits of the study, it was interesting to report the positive effects of the therapeutical association, vitamins and beta-alanine, after a combined radio-surgical treatment of patients with squamous cell carcinoma of upper aerodigestive tract.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • CD4-CD8 Ratio
  • Calcitriol / analogs & derivatives
  • Calcitriol / blood
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / secondary
  • Carotenoids / blood
  • Chemotherapy, Adjuvant
  • Drug Combinations
  • Humans
  • Hypopharyngeal Neoplasms / drug therapy*
  • Hypopharyngeal Neoplasms / pathology
  • Lymphocyte Activation / drug effects
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Survival Rate
  • Time Factors
  • Tonsillar Neoplasms / drug therapy*
  • Tonsillar Neoplasms / pathology
  • Vitamin A / blood
  • Vitamin E / blood
  • Vitamins / administration & dosage
  • Vitamins / blood
  • Vitamins / therapeutic use*
  • beta Carotene
  • beta-Alanine / administration & dosage
  • beta-Alanine / blood
  • beta-Alanine / therapeutic use*

Substances

  • Drug Combinations
  • Vitamins
  • beta Carotene
  • carcinomedin
  • Vitamin A
  • beta-Alanine
  • Vitamin E
  • Carotenoids
  • Calcitriol