Symptomatic hyponatremia during prolonged exercise in heat

Med Sci Sports Exerc. 1993 May;25(5):543-9.


Although hyponatremia (HN) has been reported among endurance athletes, its etiology often remains uncertain and of great interest to clinicians and physiologists. This case report presents physiologic evidence regarding the etiology and development of HN during exercise in the heat. A 21-yr-old male volunteer (K.G.) unexpectedly experienced symptomatic HN during a research investigation that involved controlled sodium (Na+) intake (137 mEq Na+.d-1 for 7d) and exercise-heat acclimation (41 degrees C; 30 min.h-1, 8 h.d-1 for 10 d). Fluid balance, physiologic variables, and hematologic/hormone data were measured before and after the HN episode, with similar measurements recorded for nine unaffected volunteers. The results indicated: 1) HN was verified in K.G. (plasma Na+ < 130 mEq.l-1) after only 4 h of mild, intermittent exercise in heat; 2) K.G.'s heart rate, rectal temperature, blood pressure, and Na+ losses in sweat and urine were < or = control subjects at all times; 3) between hours 4-7, an inappropriately large release of vasopressin coincided with a decrease of urine volume to 0 ml.h-1. It was concluded that a large intake (10.3 l.7h-1) and retention (2.77 l.7h-1) of water and a "low normal" initial plasma Na+ (134 mEq.l-1) were primary factors in the development of HN in K.G., whereas Na+ losses in sweat and urine were normal and served only to exacerbate HN.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aldosterone / blood
  • Arginine Vasopressin / blood
  • Drinking / physiology
  • Exercise / physiology*
  • Hot Temperature / adverse effects*
  • Humans
  • Hyponatremia / etiology*
  • Male
  • Miliaria / etiology
  • Monitoring, Physiologic
  • Osmotic Pressure
  • Physical Endurance
  • Plasma Volume
  • Renin / blood
  • Water / adverse effects
  • Water Intoxication / complications*
  • Water Intoxication / physiopathology
  • Water-Electrolyte Balance


  • Water
  • Arginine Vasopressin
  • Aldosterone
  • Renin