Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation

Neuroscience. 1993 Mar;53(2):297-301. doi: 10.1016/0306-4522(93)90196-m.


Brain-derived neurotrophic factor is selectively expressed at relatively high levels in the rat hippocampal formation (for review, see Ref. 12; see also Refs 8, 13, 19, 20, 27) where it is thought to be involved in mechanisms of neurodegeneration and/or neural protection related to the plasticity of hippocampal neurons. Functional responses to brain-derived neurotrophic factor appear to be mediated by a tyrosine receptor kinase B with the possible involvement of the p75 low-affinity nerve growth factor receptor protein. Among the many characteristics of Alzheimer's disease is an upregulation of immune mediators in and around senile plaques in Alzheimer's disease. Recently, interleukin-1 has been shown to be detrimental to the long-term survival of embryonic hippocampal neurons in culture. Thus, if the same occurs in vivo, it is possible that the accumulation of interleukin-1 in Alzheimer's disease hippocampus may be responsible for altered hippocampal neuron synaptic plasticity. This may occur either by a direct action of interleukin-1 on hippocampal neurons or possibly indirectly by stimulating beta-amyloid production. Other indirect mechanisms may involve growth or survival factors such as the neurotrophin brain-derived neurotrophic factor which is thought to play an important role in the plastic responses of hippocampal neurons. A recent study showed that brain-derived neurotrophic factor mRNA is selectively decreased in the dentate gyrus in Alzheimer's disease. The reason(s) for the decrease of brain-derived neurotrophic factor mRNA is not known, but one possibility may be associated with the enhanced expression of interleukin-1 in the hippocampus of Alzheimer's disease patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain-Derived Neurotrophic Factor
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • Interleukin-1 / pharmacology*
  • Lipopolysaccharides / pharmacology
  • Nerve Degeneration / physiology
  • Nerve Growth Factors / biosynthesis*
  • Nerve Tissue Proteins / biosynthesis*
  • Protein-Tyrosine Kinases / biosynthesis
  • RNA, Messenger / biosynthesis*
  • Rats
  • Rats, Sprague-Dawley


  • Brain-Derived Neurotrophic Factor
  • Interleukin-1
  • Lipopolysaccharides
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Protein-Tyrosine Kinases