Statistical study of 5473 results of nine pharmacological stimulation tests: a proposed weighting index

Acta Paediatr. 1993 Mar;82(3):245-8. doi: 10.1111/j.1651-2227.1993.tb12652.x.

Abstract

A total of 5473 pharmacological stimulation tests were carried out in 3143 children and subjected to statistical analysis. The mean chronological age of the children was 9 years 9 months (range 3 years to 16 years 6 months) and mean bone age was 7 years 6 months (range 2 years to 14 years). Nine pharmacological tests were used: (1) arginine (n = 625); (2) clonidine (n = 339); (3) insulin (n = 198); (4) ornithine (n = 162); (5) insulin and arginine (n = 203); (6) clonidine and betaxolol (n = 2003); (7) L-dopa (n = 685); (8) glucagon and propranolol (n = 443); and (9) glucagon and betaxolol (n = 815). Measurement of plasma growth hormone was always performed using the same method. The distribution of values in each test was of the gausso-logarithmic type. The results of the mean peak and the 95% confidence limit were as follows: (1) 10.2, 0.45; (2) 11.5, 0.7; (3) 11.8, 0.8; (4) 14.2, 1.2; (5) 14.3, 0.9; (6) 15.7, 1.1; (7) 19.8, 2.1; (8) 20.8, 2.3; (9) 21, 2.5. These results lead to the following conclusions: the specificity of these tests is low, the mean peak may vary two-fold from one test to another, and the percentage of peaks < 10 ng/ml ranges from 69% for test 1 to 29% for tests 8 and 9. The proportion of growth hormone deficiencies thus varies considerably according to the test used.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Diagnostic Uses of Chemicals*
  • Female
  • Growth Disorders / blood
  • Growth Disorders / diagnosis*
  • Growth Hormone / blood
  • Growth Hormone / deficiency
  • Humans
  • Male
  • Pharmaceutical Preparations*
  • Retrospective Studies
  • Sensitivity and Specificity

Substances

  • Diagnostic Uses of Chemicals
  • Pharmaceutical Preparations
  • Growth Hormone