Campylobacter Jejuni Strains From Patients With Guillain-Barré Syndrome Belong Mostly to Penner Serogroup 19 and Contain beta-N-acetylglucosamine Residues

Ann Neurol. 1993 Mar;33(3):243-7. doi: 10.1002/ana.410330304.

Abstract

Campylobacter jejuni was isolated from stool cultures from 14 (30%) of 46 patients with Guillain-Barré syndrome and from 6 (1.2%) of 503 healthy persons, and the difference was highly significant (p < 0.0001). In addition, serological evidence of recent C. jejuni infection was found in 5 of 29 patients with negative stool cultures. Therefore, 41% of patients were associated with C. jejuni infection. Ten of 12 (83%) isolates from patients with Guillain-Barré syndrome belonged to Penner serogroup 19, which is a rare serogroup in sporadic patients with C. jejuni enteritis. In the lectin typing study, all serogroup 19 strains from patients with Guillain-Barré syndrome were shown to contain terminal beta-N-acetylglucosamine residues on their cell surface, but serogroup 19 strains from patients with enteritis were not.

MeSH terms

  • Acetylglucosamine / metabolism*
  • Adolescent
  • Adult
  • Antibodies, Bacterial / analysis
  • Campylobacter jejuni / immunology
  • Campylobacter jejuni / isolation & purification*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polyradiculoneuropathy / metabolism
  • Polyradiculoneuropathy / microbiology*

Substances

  • Antibodies, Bacterial
  • Acetylglucosamine