A new therapeutic approach to dialysis amyloidosis: intensive removal of beta 2-microglobulin with adsorbent column

Artif Organs. 1993 Apr;17(4):240-3. doi: 10.1111/j.1525-1594.1993.tb00574.x.


Amyloidosis, in which amyloid protein consists of beta 2-microglobulin (beta 2-M), is both a common and a serious complication of long-term hemodialysis. The mechanism of its development is not completely understood. Since beta 2-M is an amyloid protein, it is essential to try to remove as much of it as possible. A specific adsorbent of beta 2-M has been developed for use in direct hemoperfusion. The adsorbent is a porous cellulose bead to which hydrophobic organic compound is bound covalently. A combination of a high-flux membrane dialyzer and an adsorption column (BM-01) would make it possible to efficiently eliminate beta 2-M. Dialysis with a combination of direct hemoperfusion (DHP) and an adsorption column led to the elimination of more than 200-300 mg of beta 2-M. We observed 5 patients who received treatment with this column (BM-01) in combination with high-flux dialysis 3 times a week for periods of 1 week (3 patients), 6 months (1 patient), or 14 months (1 patient). It is demonstrated that the adsorbent column (BM-01) provides an intensive method to eliminate beta 2-M from the blood with no serious adverse effect. It thus has the potential to suppress the progression of dialysis amyloidosis. The use of this adsorbent column (BM-01) in combination with a high-flux dialyzer may present an improved approach to removing beta 2-M from the body.

Publication types

  • Case Reports

MeSH terms

  • Adsorption
  • Amyloidosis / etiology*
  • Amyloidosis / therapy*
  • Arthritis / etiology
  • Carpal Tunnel Syndrome / etiology
  • Female
  • Glomerulonephritis / therapy
  • Hemoperfusion*
  • Humans
  • Kidneys, Artificial*
  • Male
  • Membranes, Artificial
  • Middle Aged
  • Renal Dialysis / adverse effects*
  • Renal Dialysis / methods
  • beta 2-Microglobulin*


  • Membranes, Artificial
  • beta 2-Microglobulin